Automatic arrhythmia diagnosing system

ABSTRACT

An automatic arrythmia diagnosing system for diagnosing heart disease employs a plurality of detector elements for detecting both the components and the time interval between components of the portions of an electrocardiagraph wave. The values of cardiac potentials which are detected during one cardiac cycle are compared with those of a later cardiac cycle when the frequency of the presence of the arrhythmia is high. The number of cardiac potentials of a cardiac cycle is averaged over a predetermined number during an earlier cardiac cycle when the frequency of the presence of arrhythmia is low. Digital logic circuitry is employed to be responsive to code signals representative of various portions of the electrocardiagraph signal to produce signals indicative of different forms of heart disease.

United States Patent Abe et al. [45] Apr. 25, 1972 [54] AUTOMATIC ARRHYTHMIA 3,554,187 1/1971 Glassner "128/2 06 A DIAGNOSING SYSTEM 3,438,367 4/1969 Karsh et a1.. .....128/2.06A

' 3,510,765 5/1970 Baessler ..128/2.06 A

[72] inventors: Zenmon Abe; Takaji Suzuki; Masayuki 3,518,983 7/1970 Jorgensen.... ......128/2.06A

Tsuneoka, all of Kokubunji-shi; Eiichi Kimura, Tokyo; Teizo-Akazome, Tokyo;-

Kanji Obayashi, Tokyo; Gengo Kasai, Tokyo, all of Japan [73] Assignee: Hitachi, Ltd., Tokyo, Japan 221 Filed: Apr. 11, 1969 211 App]. No.: 815,291

[30] Foreign Application Priority Data May 20, 1968 Japan ..43/336 00 [52] US. Cl. ..l28/2.06 A [51] Int. Cl. ..A61b 5/04 [58] Field of Search ..128/2.05 P, 2.05 S, 2.05 T, 128/206 A, 2.06 F, 2.06 R

[ 56] References Cited UNITED STATES PATENTS 3,216,261 11/1965 Brown et al. ..128/2.05 P

Primary Examiner-William E. Kamm Attorney-Craig, Antonelli and Hill [57] ABSTRACT An automatic arrythmia diagnosing system for diagnosing heart disease employs a plurality of detector elements for detecting both the components and the time interval between components of the portions of an electrocardiagraph wave. The values of cardiac potentials which are detected during one cardiac cycle are compared with those of a later cardiac cycle when the frequency of the presence of the arrhythmia is high. The number of cardiac potentials of a cardiac cycle is 13 Claims, 28 Drawing Figures RR INTERVAL DETECTOR DETECTOR RR INTERVAL DETECTOR HR 2 5 W2 FIG. lo

Ix RR INTERVAL DETEcT R 9 RR INTERVAL DETECTOR IO PO INTERVAL Y DETECTOR VF s QRS COUN- COUEI COUN- CQUN- QRS DURATION L ggg T R TER R T-R DETECTOR R I NATOR HA Hi3 ||c MD 2 J P WAVE COUNTER DETECTOR \4 K5 QTE SIGNAL GENERATOR KFIDRPSETARING i PULSE T DISCRIMINATOR COUNTER mvmons zLwMo/v ABE, 'I'AKA'J'I SUZUKI, VMsAyuK TsunsokA, IcHI'KIMM A,

T5110 AKAH/ME, M1171 0BAyA5 I dn BY GENGO KASAI @Wql4 [t W W ATTORNEYS PATENTEBAPR 25 I972 sum on HF 12 F|G.4o ga a F|G.4d

FIG 4e Oulol F F --INVERTER FIG. 5

SHIFT REGISTER Imoz lmos INVENTORS TAKATZI suz MKI,

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mm mm c v? mm INVENTORS "NW/V TAKAVI 51-41 KI,

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AEN/VloN AB M/ISAYMKI TSH/VEOKAI EIZCHI K M M TEZ'ZO AKAZOME, KANTI OBAYASHI, dnd

(aENGo KASAZ SHEET 10 [1F 12 INVENTORS ZEN/MON ABE TAKA7I sulukl,

MASAY KI TSQNE KA, EIICH KIM A T'EZZO AKAZOME, TANYI OBAYASHI dnJ ENGo KASBL M.H&WIL,M w ATTORNEYS PATENTEDAPR 25 m2 BEQQWE 3,658,055 saw 11 0F 12 PATENTEQ APR 2 5 1972 5% mfiwamm Elm 530 6 A C $1 EH28. Elm i. 8 20w F A 0 2% $585 Kim 2m M38 Em 0 M83 Emma 02% mfiwmwm Kim L n: 2m II! 2% $58K Kim L Em .50 m i \W mm mm o L m J 10 m 6 $28K Kim mm 91 m Q m Om mm fia Palm KEEmsEDE INVENTORS zE/vMo/v ABE, TAKAJ'I SUZUKI M/LSAYuKI TSMNEoAA E IM lrzm m 151x) div/mums KA/vvl: aBAYA HL' dn BY LvE/VGD KASAZ Midi M H w ATTORNEYS BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a system for diagnosing arrhythmia resulting from irregularity of stimulation generated at the sinus node of the heart, generation of stimulation at a part other than the sinus node, or disorder of an excitation conduction system.

2. Description of the Prior Art Heretofore, diagnosis of arrhythmia has been done on the basis of an electrocardiogram corresponding to each cardiac cycle or heart beat. However, for this diagnosis an accumulation of knowledges and experiences'has been necessary for a long time, and this diagnosis is one of the perplexing ones among the usual clinical examinations.

Therefore, it has been desired to exploit apparatuses for automatically diagnosing arrhythmia by employing the recent electronic technology.

SUMMARY OF THE INVENTION It is an object of the present invention to provide an apparatus for diagnosing arrhythmia by the presence of the basic rhythm of cardiacaction with respect to the case where arrhythmia occurs frequently and the case where the frequency thereof is low.

Generally, as modes of arrhythmia there are two cases where disorder of stimulation or conduction of excitation occurs frequently and where the frequency thereof is low. In the former case disorderly cardiac action is detected by simultaneously analyzing electrocardiograms for several cardiac cycles, and in the latter case by first detecting information concerning electrocardiograms representing the basic rhythm of cardiac action that the stimulation generated at the sinus node is transmitted to the atrium, atrio-ventricular node, and finally to the ventricle, and by comparing each cardiac action with the said information. 7

Therefore, when the frequency of arrhythmia is low, it is necessary to know the interval between R-waves (hereinafter referred to as RR interval), the interval between P-wave and Q-wave (hereinafter referred to as PO interval), and the width of QRS wave (hereinafter referred to as QRS duration) of the said basic cardiac cycle (or heart beat). However, since these values more or less vary in each cardiac cycle, it is necessary to obtain average values thereof over several cardiac cycles.

For this reason, in the present invention, since in a normal cardiac cycle one P-wave is included and the QRS duration is substantially equal to the preceding one, a cardiac cycle including one P-wave and such QRS duration is regarded as a basic cardiac cycle. Cardiac cycles are classified according to the values of RR intervals, and the mean values of the RR interval, PO interval, and QRS duration are sought for each RR. interval. At the same time the total number of cardiac cycles and classified outputs of the values of the RR intervals are counted, and the presence of the basic rhythm is determined according to whether or not approximately 20 to 30 percent of the total number of cardiac cycles falls in the same classified RR interval.

BRIEF DESCRIPTION OF THE DRAWINGS Some embodiments of the present invention will now be described with reference to the accompanying drawings, in which: I

FIGS. 1a and 1b are a two-part block diagram of a significant part of an embodiment of the invention;

FIGS. 2a to 2g are waveforms for explaining the invention;

FIG. 3 is a block diagram of a signal generator utilized in the present invention;

FIGS. 4a to 4e are waveforms for explaining the operation of the signal generator ofFIG. 3;

FIGS. 5 to 9b are block diagrams of various parts of the embodiment of FIG. 1;

FIGS. 10 to 13 are block diagrams of various parts of an embodiment ofthe invention;

FIG. M is a waveform of cardiac potential of arrhythmia;

FIG. 15 is a block diagram of a significant part of an embodiment of the invention; and

FIG. 16 is a table utilized for diagnosis of arrhythmia according to the invention.

DESCRIPTION OF THE PREFERRED EMBODIMENT Referring to FIG. la, which is the left-hand portion of the block diagram showing a significant part of the system according to the invention for detecting the presence of a basic rhythm from the number of P-waves and the QRS duration and, when the basic rhythm is present, for obtaining the RR interval, PQ interval, and QRS duration thereof, reference numeral 1 designates a QRS duration detector for detecting the width of a QRS wave in an electrocardiographic signal. For this QRS duration detector 1 a signal described in the copending U.S. Pat. application Ser. No. 815,305, filed Apr. 1 l, 1969 entitled E.C.G. Processing System, that is, a signal as shown in FIG. 2a is utilized. The cardiac potential of FIG. 2a is first differentiated by a differentiator, and then fed to Schmitt trigger circuits having positive and negative thresholds. An output of the Schmitt trigger circuit having a negative threshold is inverted in its polarity. These inverted and non-invetted outptits are fed to an OR circuit, the fall portion of the output of which is delayed to obtain a square wave signal (hereinafter referred to as DDQS signal) corresponding to P- wave, QRS wave and T-wave in the said cardiac potential as shown in FIG. 2b. On the other hand, by utilizing the fact that the peak of the differentiated cardiac potential obtained by differentiating the said cardiac potential surely lies on the QRS wave (since the variation of the QRS wave is most abrupt among waves in the cardiac potential as is understood from the waveform of FIG. 2a, the largest differential is at the QRS wave) the peak value is detected. The detected peak value is converted into a signal having a magnitude of 60 to percent of the peak value, which signal is utilized to operate a pulse signal oscillator to obtain a square wave signal as shown in FIG. 20 (hereinafter referred to as QRSS signal). Then the coincidence of the DDQS and QRSS signals is taken at an AND circuit. Finally by controlling the integration of an interval integrator for producing sawtooth waves with the rise and fall portions of the coincident DDQS signal and by sampling and holding an output voltage 'from the integrator a voltage proportional to the width of the QRS wave can be obtained. The difference between a QRS duration derived from the QRS duration detector 1 and the QRS duration of the preceding cycle does not exceed 20 msec. in the case of the normal cardiac cycle.

a signal (hereinafter referred to as QTE signal) representing the time QT from a Q-wave to a T-wave to indicate the completion of each cardiac cycle. The construction of the QTE signal generator 3 is shown in FIG. 3. Since the time from a Q-wave to a T-wave can physiologically be represented by the formula QT 0.2 RR,, 0. l2 (see) where QT,, QT time of nth cardiac cycle,

RR,, time interval between R-waves of (21-1 )th and nth cardiac cycles,

a pulse signal generated after the lapse of this time is a QTE signal.

In the QTE signal generator of FIG. 3 a 'QRSS signal as shown in FIG. 4a is fed to a monostable multivibrator MM, through an input terminal In to generate a pulse signal as shown in FIG. 4b. An output of the multivibrator MM, is fed to a sample hold circuit SH. As a result a pulse signal as shown in FIG. 4c is generated by the multivibrator MM,, and resets an interval integrator IT for sawtooth wave generation, the

operation of which is instantaneously interrupted as shown in FIG. 4d. The voltage at that time (the peak voltage) is held by the sample hold circuit SH, and then the integrator IT is reset to initiate the next integration operation. The voltage held in the hold circuit SI-I .is transformed into a voltage of 0.2 times multivibrator circuit MM after a time of 0. l 2 sec. has elapsed from the generation of the output of the comparator CO. Thus, a pulse signal satisfying the above formula, i.e., a QTE signal is obtained at an output terminal 0 A P-wave counter 4 for counting the number of P-waves in FIG. la extracts only P-waves from a cardiac potential and counts them. As disclosed in the aforementioned copending application No. 815,305, the P-wave counter 4 is as shown in FIG. 5. A QRSS signal is fed to a flip-flop 141 through an input terminal I,, to set the flip-flop 141..Then a QTE signal as shown in FIG. 2d is fed to the flip-flop 141 through an input terminal I to reset the flip-flop 141 from which a pulse signal, FF, signal as shown in FIG. 2e, is obtained. An OR-circuit I42 delivers, in response to the FF signal and a DDQS signal as shown in FIG. 2b which is fed through an input terminal 1 a signal as shown in FIG. 2f, wherein a QRS wave and a T-wave form a square wave, to a shift register 143 which is set suchthat-the total transmission time is 100 msec. Since the duration of a square signal corresponding to a P-wave in a DDQS signal is usually 100 nisec. or less, the square signal passes through the shift register 143 and an AND-circuit 144 to obtain a square signal as shown in FIG. 2g (hereinafter referred to as DDQS-P signal) at an output terminal Q In contrast, since the time interval between a QRS wave and a T- wave is usually 300 to 400 msec., and since the transmission time of the shift register is 100 msec., and AND-circuit 145 is inevitably fed with the entire input at the time of the transmission of the square signal composed of the QRS wave and T- wave. As a result a flip-flop 146 is set by an output from the AND-circuit l45,'and an output' signal from the flip-flop 146 is fed to the inhibit terminal of the AND-circuit 144 to inhibit the input thereof. Consequently, the output terminal O but instead the output from the shift register 143 is reversed in its polarity by an inverter 147 and fed to the flip-flop 146 to reset it.

In this manner, only a square signal corresponding to P- waves as shown in FIG. 2g is obtained at the output terminal O Thus, the P-wave can bedetected. Consequently, if a rise portion of this square wave is employed as a trigger for a monostable multivibrator circuit set at approximately 100v msec. in its duration, the number of P-waves can be obtained by counting the output of the said monostable multivibrator circuit with a counter constituted by a flip-flop circuit. Thus, even if there are two P-waves between successive T- and Q- waves, they can be counted by the counter.

A detector 5 in FIG. 1a for deriving one P-wave from the P- wave counter 4 is constituted an AND circuit. If there are two P-waves, one output of thecounter 4 is'inhibited not to generate an output from the AND circuit. Thus, always only signals comprising one P-wave can be detected.

An interval between a P-wave and the next P-wave (PP interval) can be obtained by an arrangement as shown in FIG. 6. A DDQS-P signal as shown in FIG. 2g is fed to a monostable multivibrator MM through an input terminal I to trigger the multivibrator MM with the rise portion'of the signal to generate a pulse signal having a duration of I00 msec.which is equal to the width of the P-wave. This pulse signalis fed to a monostable multivibrator MM and a pulse signalfrom the multivibrator MM, is fed to a sample hold circuit SH and another pulse signal therefrom is fed to a monostable multivibrator MM As a result, a sample hold circuit SI-I samples to hold the output from an interval integrator IT employing a sawtooth wave generating circuit, for example. The held voltage is derived from an output terminal O The integrator IT is instantaneously reset by the output from the multivibrator MM to resume its operation. Thus, by the application of the next DDQS-P signal the integrator IT,, is reset, and the integrated value, i.e., voltage at the time of the reset is sampled to be held by the sample hold circuit SH to obtain a voltage representing the interval between a DDQSP signal and the next DDQS-P signal, i.e., between a P-wave and the next P- wave. C in, FIG. 6 represents the aforementioned counter for counting the number of P-waves. This counter (1,, counts pulse signals from the multivibrator. MM triggered by a DDQS-P signal.

A PO interval detector 6 in FIG. la for detecting the interval between a P-wave and the succeeding Q-wave in a cardiac potential employs an arrangement as shown in FIG. 7. In FIG. 7, FF, is a flip-flop circuit, OR, is an OR circuit, SR; is a shift register (the entire transmission time is set at I00 msec.), and AND-, and AND are AND circuits. Square signals similar to those described with reference to FIG. 5, i.e., signals as shown 1 in FIGS. 2b, 2c, and 2d are fed to the arrangement of FIG, 7 through input terminals l l and ["703 to obtain a DDQS- P signal as shown in FIG. 2g from an AND-circuit AND with an operation similar to the arrangement of FIG; 5. The rise portion of the DDQS-P signal triggers a monostable multivibrator MM, which in turn triggers another monostable multivibrator MM by its pulse output. An interval integrator IT employing a sawtooth wave generator for example, is instantaneously reset by a pulse output having, for example, a

duration of 5 msec. from the multivibrator MM to resume its operation. The output from the AND-circuit AND is fed to the inhibit terminal of the AND-circuit AND and also to a monostable multivibrator MM Thus, the multivibrator MM- istriggered by the rise portion of a square wave composed of a QRS wave and a T-wave. A sample hold circuit SH; is operated by a pulse output having a duration of for example, 5 msec. form the multivibrator MM to provide a voltage corresponding to the output from the integrator 1T i.e., the interval between a P-wave and a Q-wave at an output terminal 71701" An RR interval detector 7 in FIG. la for detecting the interval between R-waves as a voltage has the same arrangement as that of FIG. 3 from which the divider D, and the monostable multivibrator circuit MM are eliminated. The RR interval is detected at the output of the comparator CO as a voltage proportional to the RR interval. Reference numeral 8 designates a counter constituted by a flipflop for counting the output from the QTE signal generator 3. Reference numeral 9 designates an AND circuit fed with the outputs from the QRS duration detector 2, detector 5 for detecting one P-wave, and QTE signal generator 3 as its inputs. Reference numeral 10 designates an RR interval detector constituted by a shift register SI-IR and OR-circuits OR as shown in FIG. 8. To classify cardiac cycles according to the RR interval, RR intervals are classified into the following four kinds: 0.5 to'0.7 sec. 0.6 to 0.9 sec. 0.8 to 1.2 sec. 1.0 to 1.5 sec. In order to determine to which RR interval of the above four kinds a cardiac cycle belongs the shift register SHR in the RR interval detector I0 feeds each OR-circuit OR with a plurality of its outputs to be applied to the preceding stage of an OR circuit together with a plurality of its outputs to be applied to the succeeding stage of an OR circuit as the-inputs thereto.

Each of counters 11A to MD in FIG. la is constituted by a flip-flop circuit for counting the output from the RR interval detector 10 and generates an output when it counts a predetermined number or more, for example, four or more. If there occur four or more cardiac cycles belonging to the same RR interval among 16 cardiac cycles'to be measured, this implies that there is a basic rhythm because the proportion of the occurrence of cardiac cycles belonging to the same RR interval is four-sixteenths, i.e., 25 percent or more.

Reference numeral 12 in FlG. la designates an OR circuit fed with the outputs from the counters 11A to MD. Numeral 13 designates a first appearing pulse discriminator for discriminating whether the output from the counter 8 or the output from the OR-circuit 12 is fed earlier thereto. The discriminator 13 is constituted by AND-circuits IN, and IN and flip-flops FF, and FF as shown in FIG. 9a. The flip-flops F F, and FF are supplied with a start signal through an input terminal 1, to be reset. Therefore, if the output from the OR-circuit 12 is fed to the AND-circuit IN, through an input terminal l,,,,, the flip-flop FF, is set. The output signal from the flip-flop FF, inhibits the AND-circuit 1N Thus, an output appears only at an output terminal 0 to indicate that the output from the OR-circuit 12 is preceding. Conversely, if the output from the counter 8 is fed to the AND-circuit IN, through an input terminal 1, output is obtained only at an output terminal of the flip-flop FF, to indicate that the output from the counter 8 is preceding.

The arrangement of FIGS. 1a and lb further comprises, as shown inYFIG. 1b, mean value detectors 14a to 1411 which are fed with the output from the QRS duration detector 1 as their input and which are commanded by the RR interval detector to add the input, mean value detectors a to 15a which are fed with the output from the PQ interval detector 6 as their input and commanded by the RR interval detector 10 to add the input, and mean value detectors 16a to 16d which are fed with the output from the RR interval detector 7 as their input and commanded by the RR interval detector 10 to add the input. Each of the mean value detectors is constituted by an adder ADD, sample hold circuits SH, and 5H a divider DV, and an inverter IN, as shown in FIG. 9b. The said input is fed through an input terminal In to the adder ADD, the output of which is sampled and held at the sample hold circuit SH, in accordance with the addition command signal fed to the sample hold circuit SH, through an input terminal l The said command signal is reversed in its polarity by the inverter [N and hence the output of the sample hold circuit SH, is not transferred to the sample hold circuit 5H while the command signal is present. When the command signal is absent, the sample hold circuit 5H operates to transfer the output of the sample hold circuit SH, to the sample hold circuit SH at which the transferredoutput is sampled and held and the output of which is fed back to the adder ADD. An input to the adder ADD detected in the next cardiac cycle is added to the preceding input, and the output from the adder ADD is sampled and held at the sample hold circuits SH, and 8H according to the command signal, and this operation is repeated for each cardiac cycle. The final output is derived from an output terminal O at which time an output divided by the number of times of addition by the divider DV, is obtained. Reference numerals 17a to 17d in FIG. 1b designate analog gates on-off controlled by the outputs from the counters 11A to 11D to derive the outputs from the mean value detectors 14a to 14 d, respectively, Numerals 18a to 18! designate analog gates onoff controlled by the outputs from the counters llllA to 119 to derive the outputs from the mean value detectors 15a to 15d, respectively, and numerals 19a to 19d designate analog gates on-off controlled by the outputs from the counters 11A to 11D to derive the outputs from the mean value detectors 16a to 16d, respectively. I", is a terminal to which a signal for resetting the mean value detectors is fed, 0 is a terminal for deriving the output from the first appearing pulse discriminator l3, and 0, to 0 are output terminals of the analog gates 17a to 17d, 18a to 18d, and ll9a to 19d, respectively. I

During the operation of the arrangement of FIGS. la and 1b, the QRS duration of each cardiac cycle is compared with the QRS duration of the preceding cardiac cycle at the QRS duration detector 2. If the QRS duration is within the normal range of 20 mseo, the output from the QRS discriminator 2 is fed to the AN D-circuit 9. If the number of P-waves is one, the output of the detector 5 is fed to the AND-circuit R. Further,

the QTE signal indicating the end of each cardiac cycle from the QTE signal generator 3 is fed to the AND-circuit 9. As a result, only a normal cardiac cycle having the QRS duration within the normal range and one P-wave and indicating the end ofa cardiac cycle is detected by the AND-circuit 9. Since the output from the AND-circuit 9 corresponding to each cardiac cycle is fed to the RR interval detector 10, the periodicity of the output of the AND-circuit 9 is detected by the RR interval detector 10. The cardiac cycles detected and classified in the RR interval detector 10 are counted by the corresponding counters 11A to 11D, respectively. At the same time the outputs from the QRS duration detector 1, PO interval detector 6, and RR interval detector 7 are fed to the mean value detectors 14a to 14d, 15a to 15d, and 16a to 16d, respectively, and the classified outputs from the RR interval detector 10 are fed to the mean value detectors 14a, 15a, 16a; 14b, 15b, 16b; 14c, 15c, 16c: and 14d, 15d, 16d, respectively, as their addition command signals. Each mean value detector receiving the ad dition command signal performs the addition of the QRS durations, PQ intervals or RR intervals to generate an output of Ur: of the added value, where n is the number of times of addition.

The counters 11A to 111) generate output signals when they count four outputs each from the RR interval detector 10, and

open the analog gates 17a to 19d to derive the outputs from the corresponding mean value detectors 14a to 16d as values of the basic rhythm. For example, the counter 11C for counting the outputs from the RR interval detector 10 corresponding to the time of 0.8 to 1.2 sec. generate an output signal when it counts four outputs. This output signal opens the analog gates 17c, 18c, and to obtain a mean QRS duration, a mean PQ interval, and a mean RR interval from the mean value detectors 14c, 15c, and Me at the output terminals 0 0 and 0 respectively.

The just described operation is effective when a signal is obtained from the output terminal of the first appearing pulse discriminator 13. Since the output signal from the QTE signal generator 3 is also fed to the counter 8, the counter 8 counts the number of the cardiac cycles. If the counter 8 is set such that it generates an output signal when it counts 16 cardiac cycles, the output signal is fed to the first appearing pulse discriminator 13 when the counter 8 counts 16 cardiac cycles. The first appearing pulse discriminator 13 is also fed with the output from the OR-circuit 12. Since the OR-circuit 12 generates an output signal when four signals from the counter 11A to 111) are present, if the output signal from the OR-circuit 12 appears earlier than the output signal from the counter 8, it means that four cardiac cycles out of the 16 cardiac cycles belong to one of the classified RR intervals, that is, it is considered that four-sixteenths, i.e., 25 percent or more of similar cardiac cycles are present. Since this is considered to be the aforementioned basic rhythm, the QRS duration, PQ interval and RR interval obtained at the output terminals 0,, to O are values when the cardiac action has the basic rhythm. When the output signal from the counter 8 appears earlier than the output signal from the OR-circuit 12, the first appearing pulse discriminator 13 generates no output signal, in which case it is considered that there is no basic rhythm. in this case the counters 11A to MD generate no output, and hence no QRS duration, PQ interval, and RR interval are obtained.

The criterion of whether or not there is a basic rhythm and the classification of the RR intervals are determined by experience of clinical diagnosis.

in this manner, when there is the basic rhythm in the cardiac action of several cycles, the QRS duration, PQ interval and RR interval in the cardiac cycle are detected as mean values over several cardiac cycles. Then, the QRS duration, PQ interval, and RR interval on the electrocardiogram of a test subject are compared with those of the basic rhythm to diagnose a heart disease. in this case, since it has been known by experience of diagnosis that when what relation is there between the detected values of the basic rhythm and the detected values of a subject, what disease it indicates, the characteristics represented by the relation between the detected values of the basic rhythm and the subject are coded. The diagnosis of a heart disease is done by a combination of the coded relations.

In the table of FIG. 16, RR, represents the amount of RR intervalin the basic rhythm, and RR, represents that of a subject. When RR and RR,, have, for example, a relation RR /RR 0.85, then the RR interval is coded asRB and the case 1.2 RRn/RR 0.85 is coded as RB,,. Rm and R are codes when the relations shown in FIG. 16 are satisfied.

n represents the number of Pwaves, and when n 1, that is, when there is the basic rhythm, the n,, is coded as I and according to the number of n, it is coded as l 1, and I as shown in the table of FIG. 16.

PP represents the interval between P-waves of one cardiac cycle and the next cardiac cycle, and when it satisfies, for example, a relation PP 0.3 sec., it is coded as PP, PP is also a code when it satisfies the relation shown in FIG. 16.

FO is the amount of the PQ interval of the basic rhythm, PQ v is that of the subject, and I-"Q,, is that in the preceding cardiac cycle of the subject. When PO and PQ,, have a relation \PQ PQnl g 20 msec., it is coded as P0,;, and P0,

PQ,, PO and PQ are codes when they have the relations are satisfiedas seen from FIG. 16, these codes can be obtained by appropriately combining the following formulas:

RR, 0.85 RR RR,, 1.2 RR,, (6) RR,, 1.8 RR,; (7)

In the present invention, the combinations of these formulas are realized by an arrangement as shown in FIG. 10. RR is fed to comparators 21a to 21c through an input terminal In at which time RR fed to the comparator 21a is multiplied by 0.85 by a divider 20a. The comparators 21a to 210 are also fed with RR, through another input terminal In at which time RR,, fed to the comparator 21b is multiplied by 1/ 1.2 by a divider 20b, and RR fed to the comparator 21c is multiplied by 1/1 .8 by a divider 20c. As a result, the comparators 21a to 210 generate outputsignals when they satisfy formulas (5) to (7), respectively. The output signal from the comparator 21a is fed to an AND-circuit 22a as an inhibit input signalnThe output signal from the AND-circuit 22a is fed to a flip-flop 24a and OR-circuits 23b to 23d. The flip-flop 24a is set by the output signal from the AND-circuit 22a to provide an output signal representing the code R8,,. at an output terminal O,, An AND-circuit 22b is fed with the outputs from the comparators 21a and 21b, but the output from the comparator 21b is an inhibit input to the AND-circuit 22b, that is, formula (7) is not satisfied. The output signal from the AND-circuit 22b is fed to a flip-flop 24b and the OR-circuits 23a, 23c, and 23d. The flipflop 24b is set by the output signal from the AND-circuit 22b to provide an output signal representing the code R8,, at an output terminal O Since an AN D-circuit 220 is fed with the outputs from the comparators 21b and 21c, formulas (6) and (7) are satisfied. The output signal from the AND-circuit 220 is fed to a flip-flop 24c and the OR-circuits 23a, 23b, and 23d. The flip-flop 240 is set by the output signal from the AND-circuit 220 to provide an output signal representing thecode RB, at an output terminal O A flip-flop 24d is fed with the output from an AN D-circuit 22d as its input signal which does not satisfy formula (7), that is, indicates RR,, 1.8 RR,,. As a result, formula (6) represented by the output signal of the comparator 21b is neglected. The flip-flop M dis set by the output signal from the AND-circuit 22a to provide an output signal representing the code R I? at an output terminal O Since formulas IPQ PQ I e 20 msec. (s) I Qn PQHI 20 msec. (9) have only to be satisfied to obtain PQ and P050, respectively, as seen from FIG. 16, the following formulas I PQ" PQ 20 msec. (10) PQ1. PQ msec. (11) can be obtained from formula (8) if PQ" PQu, and the foilowing formulas PQ PQ 20 msec. (l2) PQ PC) 20 msec. (13) can be'obtained if PO PQ When formulas l 1) and 13) are satisfied, F'Q,,, is obtained, otherwise PQ is obtained.

Therefore, if a comparator a is fed with a voltage corresponding to 20 msec., P08: and PQn through input terminals In In and In respectively, and if a comparator 25b is fed with the voltage corresponding to 20 msec., P0, and PQ through the input terminals In In and In respectively, as shown in FIG. 11, the comparator 25a generates an output signal when it satisfies formula (1 1) and the comparator 25b generates an output signal when it satisfies formula 12). When the comparators 25a and 25b generate the output signals simultaneously, both these output signals are fed to an AND-circuit 26, the output signal of which sets a flip-flop to obtain PO at an output terminal 0 When no output signal is obtained at the terminal O the comparators 25a and 25b are in a 0 state. In this case, the output signals from the comparators 25a and 25b are converted by inverters 28a and 28b into signals in 1 state. The output signals from the inverter 28a and 28b are fed to an OR-circuit 29, the output signal of which is fed to an AND-circuit 30. The flip-flop 27 is reset by the output signal from the ANDcircuit 30. The flip-flop 27 is reset by the output signal from the AND-circuit 30. The flipflop 27 is reset by the output signal from the ANDcircuit 30 to provide PQ at an output terminal O and PQ at the output terminal 0 By replacing PQ" and PQ by QRS and QRS respectively, in the above description the codes QDB, and QDB, can beobtained.

The other codes shown in FIG. 16 can also be obtained by similar means except that for P+ and P', which are the codes of positive and negative polarities of the P-wave, a combination of output signals from Schmitt trigger circuits having positive and negative thresholds and the first appearing pulse discriminator shown in FIG. 9a are employed.

Diagnosis of arrhythmia by the use of the codes obtained in the manner as described above is done by combining the codes. As an example, diagnosis of arrhythmia resulting from an atrio-ventricular block or a ventricular extrasystole will be described. As regards the atrio-ventricular block, since the stimulation produced at the sinus node is blocked at the atrio ventricular node in the course of transmission from the atrium to the ventricle, there occur two, sometimes three, P-waves, the RR interval is very long compared with RR,,, and yet the QRS duration and the PQ interval are invariant. Therefore, if this atrio-ventricular block occurs, the code is the com combination of R8,, or R8,, 1P or 1P PO and QDB (shown by the mark X in FIG. 16). In case the ventricular extrasystole occurred subsequent to the cardiac action having the basic rhythm, a stimulation occurs in the ventricle. In this case, since the atrium does not contract, the RR interval is short, and the QRS duration is long, the code is a combination of R318. IP,,, and one. (shown by the mark x in FIG. 16). In this manner other arrhythmias also can be diagnosed by the combination of codes as indicated by the mark X in FIG. 16.

For the combination of codes for the atrio-ventricular block an arrangement as shown in FIG. 12 is employed. Signals representing the codes R B, and R8 are fed to an OR-circuit 31, and signals representing the codes 1,, and 1, are fed to an OR-circuit 32. The output signals from these OR-circuits 31 and 32 and signals representing the codes PQ and GD, are fed to an AND-circuit 33. Signals representing the codes R I,,,', PO and QD which represent cardiac cycles substantially equal to the basic rhythm (sinus arrhythmia) are fed to an AND-circuit 34, the output of which is fed to an AND-circuit 35. A flip-flop 36 is set by the output from the AND-circuit 35. The output of the AND-circuit 33 is fed to an AND- circuit 37, at which time the flip-flop 36 is reset by the output of an AND-circuit 38 to feed the output thereof to the AND- circuit 37 through a delay circuit 39 where the output from the flip-flop 36 is delayed. The output from the AND-circuit 37 sets a flip-flop 40 to cause it to deliver an output signal to an output terminal 0, That is, the output signal is obtained bythe fact that the codes representing the basic cardiac action are converted into the codes representing the atrio-ventricular block; By this output signal the atrio-ventricular block can be diagnosed. Incidentally, the flip-flop 40 is adapted to be reset by a reset pulse so that the AND-circuits 35, 37, and 38 generate output signals synchronously with the reset pulse.

' Since the ventricular extrasystole occurs subsequently to the cardiac cycle having the basic rhythm, the signals of the codes representing the ventricular extrasystole are obtained in such a manner as described above. When each code is converted from RB,, into RB,,,-, from IP into [P and from QD,,,, into 'QDB the cardiac action is determined as a ventricular extrasystole. In FIG. 13, signals respectively representing the codes RB IP,, PQB, and 0D,, are fed to an AND-circuit 41, the output signal of which is fed to an AND-circuit 42. A flipflop 43 is set by the output signal from the AND-circuit 42. Signals respectively representing the codes RB, IP and OD are fed to an AND-circuit 44, the output signal of which is fed to an AND-circuit 45. At this time the flip-flop 43 is reset by the output signal of an AND-circuit 46. The output signal from the flip-flop 43 is delayed by a delay circuit 47 and then fed to the AND-circuit 45. A flip-flop 48 is set by the output signal from the AND-circuit 45 to deliver an'output signal to an output terminal 0 By this output signal the ventricular extrasystole can be diagnosed.

The other heart diseases relating to arrhythmia shown in FIG. 16 can be diagnosed in a similar manner.

Hereinabove only the cases where the frequency of the arrhythmia is low have been described. However, the present invention can also, be applied to the cases where the basic rhythm cannot be detected, that is, the frequency of the arrhythmia is high.

In the case where the frequency of the arrhythmia is high, the number of P-waves, the PQ interval, the QRS duration, and the RR interval in a few, for example four, cardiac cycles in which the arrhythmia occurs are coded in a manner similar to the case where the frequency of the arrhythmia is low. In this case, however, the coding is made with respect to the comparison not with the basic rhythm, but with the preceding cardiac cycle. By simultaneously performing the comparison of the coded RR interval, PQ interval, and QRS duration heart diseases can be diagnosed. That is, a signal corresponding to each code is fed to a shift register which successively stores the signal corresponding to the code associated with each cardiac cycle. Then the contents stored in the registers are simultaneously compared.

For example, for a bigeminy ventricular extrasystole in which an extrasystole occurs at each cardiac cycle as shown in FIG. 14, the RR interval is successively coded as RR,,, RR,, RR,, RR,. If the RR interval in the nth cardiac cycle is represented by RR and that in the (n] )th cardiac cycle is represented by RR,, the RR interval is coded as RR, when RR, and RR W, satisfy the relation RR,,/RR,, 1.2, and coded as RR, when RR,, and RR,, satisfy the relation RR,,/RR,', 0.85.

The codes of the number n,, of P-waves are I? and IP [P is when n,, is l, and IP, is when n,, is O. The QRS duration is coded as QDA,, when the QRS duration QRS of the nth cardiac cycle satisfies a relation QRS,,,, 0. l2 sec., and coded as QDA when a relation QRS, 0.12 see. is satisfied. Therefore, in the case of the said bigeminy ventricular extrasystole shown in FIG. 14, the said codes change as QDA QDA,, QDA QDA for four successive cardiac cycles. In other words, when the code of the RR interval is RR the code of the number of the P-waves is IP,,, and the code of the QRS duration is ODA When the code of the RR interval is RR, the code of the number of the P-waves is IP,, and the code of the QRS duration is QDA,,. Therefore, when these'changes of the codes occur simultaneously, the presence of the bigeminy ventricular extrasystole is determined.

Consequently, if signals representing the said codes are fed to shift registers, the content of the shift register fed with the signal representing RR, is (l0l0), the content of the shift register fed with the signal representing RR, is (0101 the content of the shift register fed with the signal representing IP, is 1010), and the content of the shift register fed with the signal representing IP, is (0101 Therefore, when the said contents of the shift registers are simultaneously present, the presence of the bigeminy ventricular extrasystole is determined.

Referring to FIG. 15, signals representing the codes RR,, RR IP,,, IP,, QDA,,, and QDA are fed to shift registers 49a to 49f, respectively. These input signals are successively shifted by the application of the output signal from a monostable multivibrator circuit 50 triggered by a set pulse indicating the end of each cardiac cycle, for example, by a QTE signal indicating the end of a T-wave. The output signals from the shift registers 49a to 49f are fed to AND-circuits 51a to 51f, respectively. When the contents of the shift registers 49a to 49f are (0101 (1010), (0101), (I010), (1010), and (0101), the AND circuits generate their output signals which are fed to an AND- circuit 52. A flip-flop 53 is set by the output signal from the AND-circuit 52 to deliver an output signal to an output terminal O By this output signal the presence of the bigeminy ventricular extrasystole is determined. The AND-circuit 52 is set by the application of a set pulse. The flip-flop 53 is reset by a reset pulse applied at the time of the start of the detection.

The number of cardiac cycles employed for the detection is not limited to four, but may be varied according to the heart disease.

Thus, the diagnosis of the bigeminy ventricular extrasystole is made possible. Other heart diseases due to arrhythmia of high frequency can also be diagnosed by coding the characteristics as to the RR interval, QRS duration, the number of P- waves, PQ interval, the polarities of P-waves, etc. obtained by experience of clinical diagnosis, and by combining the codes over several cardiac cycles.

As has been stated hereinabove, according to the invention the diagnosis of various heart diseases has become possible. Furthermore, the present invention has the advantages that mass examination of heart diseases is possible in view of a rapid increase of such diseases, and that the monitoring of the cardiac action in and after operation is possible.

We claim:

1. An automatic arrhythmia diagnosing system for determining characteristics of a cardiographic signal which includes P-, Q-, R-, S-, and T-wave portions comprising:

first means for detecting each of said wave portions of said cardiographic signals; second means, responsive to said first means, for measuring the width of a QRS wave, the interval between the P-wave and a Q-wave, the number of P-waves, the polarities of the P-waves from each of said first and second cardiac cycles of a test subject and the interval between respective R- and P-waves of a first and second cardiac cycle;

third means, responsive to said measuring means, for

producing a plurality of measurement signals representative of said wave measurements indicative of clinical diagnostic characteristics of a heart disease, and

fourth means, responsive to said measurement signal producing means, for logically combining said plurality of signals in accordance with specific relationships corresponding to symptoms of -a predetermined heart disease.

2. An automatic arrhythmia diagnosing system according to claim 1, further comprising seventh means, responsive to said first means, for converting said wave portions into respective rectangular waves and eighth means, responsive to said second and said seventh means, for generating a signal corresponding to said interval between P-waves including a first monostable multivibrator circuit for generating a pulse output having a duration of approximately 100 msec. and being trig-- gered by thefirst rise part of the rectangular waves representative of a P-wave of a cardiac potential, a second multivibrator, triggered 'by the pulse output of said first multivibrator, producing a plurality of pulse outputs, a sample holding circuit supplied with one of the pulse outputs from said second monostable multivibrator as a control signal, a third monostable multivibrator triggered by the other of saidpulse outputs from said second monostablev multivibrator, and a voltage generator reset by a pulse output of. said third monostable multivibrator, said sample holding circuit being controlledby said one of said pulse outputs from said-second monostable multivibrator to sample and hold the output voltage from said voltage generatr,said voltage generator being instantaneously reset by said pulse output of said third monostable multivibrator to resume its operation.

3. An automatic arrhythmia diagnosing system according to claim 1, comprising seventh means responsive to said first means for converting said wave portions into respective rectangular waves and ninth means responsive to said second and seventh means for generating a signal corresponding to said interval between said P- and Q-waves including a first monostable multivibrator circuit for generating a pulse output having a duration of approximately lOO msec. and triggered by the first rise pulse of the rectangular waves representative of a P-wave of a cardiac potential, at second multivibrator triggered by the pulse output from said first monostable multivibrator, a voltage generator reset by an output from said second monostable multivibrator to momentarily interrupt and then resume its operation, a third monostable multivibrator triggered by the rise part of a rectangular wave representative of the part from said Q-wave to said T-wave of a cardiac potential, and a sampling and holding circuit for sampling and holding the output of said voltage generator controlled by an output of said third monostable multivibrator.

4. An automatic arrhythmia diagnosing system according to claim 1, comprising seventh means responsive to said first 6. An automatic arrhythmia diagnosing system according to claim 5, comprising means for detecting said basic rhythm from cardiac cycles of said test subject including a shift register having a predetermined number of stages for receiving as an input signal a normal cardiac cycle having one P-wave and one QRS wave the width of which is equal to that of a preceding cardiac cycle in a predetermined number of cardiac cycles of said test subject, a plurality of first OR circuits each for receiving as its input signals outputsfrom predetermined stages of said shift register, a plurality of first counters for counting a predetermined number of output signals from each of said first OR circuits, a counter OR circuit for receiving all outputs from said first counters, a second counter for countin g said predetermined number of cardiac cycles of said test subject, and a first appearing pulse discriminator for discriminating one from the other of the output signal from said second counter and the output signal from said counter OR circuit. said shift register successively generating output signals within the time interval between 'R-waves predetermined by the number of stages and the feed time of said shift register, each of said first OR circuits receiving a part of the input signals of the immediately preceding one of said first 0R circuits.

7. An automatic arrhythmia diagnosing system according to claim 6,-wherein said first appearing pulse discriminator comprises-a first AND circuit having an inhibit terminal and an means for converting said wave portions into respective rectangular waves and tenth means responsive to said second and seventh means for generating a signal corresponding to said interval between said R-waves including a first monostable multivibrator triggered by a rectangular signal representative of an R-wave of cardiac potential producing a pair of outputs, a second monostable multivibrator triggered by one of the outputs of said first monostable multivibrator, a voltage generator instantaneously reset by an output of said second monostable multivibrator to resume its operatioma sampling and holding circuit for sampling and holding the output of said voltage generator controlled by the other of said outputs of said first monostable multivibrator and a comparator for receiving as its two inputs the output of said sampling and holding circuit and the outputs of said voltage generator, said comparator generating a voltage when its two inputs are equal to each other.

5. A system in accordance with claim 1, further comprising fifth means, responsive to said first means, for determining a predetermined number of cardiac cycles, having a basic rhythm, and further comprising sixth means responsive to said second means for generating signals representative of the mean values of the width of the QRS wave, the interval between the 'P- and Q-waves, and the interval of the R-waves.

input terminal, a first flip-flop circuit connected with said first AND circuit, a second AND circuit having an inhibit terminal and an input terminal, and a second flip-flop circuit connected with said second AND circuit, said first flip-flop circuit generating an output when an output from said counter OR circuit is applied to said input terminal of said first AND circuit, a part of said output from said first flip-flop circuit being derived from anoutput terminal thereof, the remaining part of said output from said first flipflop circuit entering said inhibit terminal. of said second AND circuit to inhibit said second AND circuit, said second flip-flop circuit generating an output when an output from said second counter is applied to said input terminal of said second ANDcircuit, a part of said output from said second flip flop circuit being derived from an output terminal thereof, the remaining part of said output from said second flip-flop circuit entering said inhibit terminal of said first AND circuit to inhibit said first AND circuit.

8. A system in accordance with claim 6, wherein said mean value signal generating means comprises an adder circuit havt ing a pair of inputs, one of which receives signals indicative of t the width of said QRS waves, a pair of sample hold circuits connected in series and being supplied the output of said adder circuit, a divider circuit connected to the output of said series connected sample hold circuits, a feedback circuit connected as one input of said addercircuit from the output of said series connected sample hold circuit, a controlled input for each of said sample hold circuits, one of which is connected to a control input terminal means, for supplying a control input signal to said control input terminal, and the other of which is connected to said controlinput terminal through an inverter circuit. I

9, A system in accordance with claim 8, further including a plurality of analog gates, respectively connected to the outputs of said mean value signal generating means and responsive to the output of said plurality of first counters for obtaining a mean value QRS duration, a mean PQ interval and a means PR interval.

10. A system in accordance with claim 1, wherein said logically combining means comprises first logic means for generating a first plurality of code signals, including a plurality of dividercircuits receiving RR integral signals, a plurality of comparatorcircuits corresponding in number to the number of divider circuits, and being connected in series therewith and receiving at one respective input the output of the respective divider circuit and another respective input a preselected RR interval signal, a set of logical AND gates connected to the outputs of said comparator circuits and to a control input therefor for receiving a gate energizing signal, and a plurality of logic storage circuits connected to the outputs of said AND gates for registering a first set of code signals.

11. A system in accordance with claim 10, wherein said logically combining means further comprises second logic means for generating second code signals representative of a second set of diagnostic characteristics, said second logic circuit means comprising a pair of comparator circuits for comparing a plurality of PO interval signals, a pair of interter circuits, receiving the outputs of said comparator circuits, a storage flip-flop beinglogically connected to said comparator circuits and means for logically connecting said inverter circuits to said storage flip-flop and for connecting the outputs of said comparator circuits to said storage flip-flop, comprising a set of second logic AND gates, the control inputs of which are connected to a means for supplying said control inputs with a common control signal.

12. A system in accordance with claim 11, further comprising means for combining the outputs of said first and second logic means, comprising a first plurality of OR gates and a set of combining AND gates connected in series therewith, an output AND gate for receiving the outputs of said combining AND gates, said output AND gate further including a control input and a means for supplying a pulse to energize said control input and delayed storage input and further comprising a storage flip-flop connected to one of said combining AND gates and a delay circuit connected in series therewith for supplying said delayed storage input, and a combining output logic storage flip-flop connected to said output AND gates for delivering an output signal whereby atrio-ventricular block can be diagnosed.

13. A system in accordance with claim 1, including coding means responsive to said first means for generating coded signals representative of coded portions of said cardiac wave signal and wherein said logically combining means comprises a plurality of shift register means, connected to said coding means to receive a plurality of signals representative of coded portions of said cardiac wave signal, a triggering multivibrator, connected in parallel to the inputs of each of said shift registers, a first plurality of shift register output gates connected to each respective shift register, and a combining output shift register AND gate connected to each of the outputs of each of said shift register output gates, and an output register flip-flop, for providing a signal indicative of the presence of bigeminy ventricular extrasystole. 

1. An automatic arrhythmia diagnosing systeM for determining characteristics of a cardiographic signal which includes P-, Q-, R-, S-, and T-wave portions comprising: first means for detecting each of said wave portions of said cardiographic signals; second means, responsive to said first means, for measuring the width of a QRS wave, the interval between the P-wave and a Qwave, the number of P-waves, the polarities of the P-waves from each of said first and second cardiac cycles of a test subject and the interval between respective R- and P-waves of a first and second cardiac cycle; third means, responsive to said measuring means, for producing a plurality of measurement signals representative of said wave measurements indicative of clinical diagnostic characteristics of a heart disease, and fourth means, responsive to said measurement signal producing means, for logically combining said plurality of signals in accordance with specific relationships corresponding to symptoms of a predetermined heart disease.
 2. An automatic arrhythmia diagnosing system according to claim 1, further comprising seventh means, responsive to said first means, for converting said wave portions into respective rectangular waves and eighth means, responsive to said second and said seventh means, for generating a signal corresponding to said interval between P-waves including a first monostable multivibrator circuit for generating a pulse output having a duration of approximately 100 msec. and being triggered by the first rise part of the rectangular waves representative of a P-wave of a cardiac potential, a second multivibrator, triggered by the pulse output of said first multivibrator, producing a plurality of pulse outputs, a sample holding circuit supplied with one of the pulse outputs from said second monostable multivibrator as a control signal, a third monostable multivibrator triggered by the other of said pulse outputs from said second monostable multivibrator, and a voltage generator reset by a pulse output of said third monostable multivibrator, said sample holding circuit being controlled by said one of said pulse outputs from said second monostable multivibrator to sample and hold the output voltage from said voltage generator, said voltage generator being instantaneously reset by said pulse output of said third monostable multivibrator to resume its operation.
 3. An automatic arrhythmia diagnosing system according to claim 1, comprising seventh means responsive to said first means for converting said wave portions into respective rectangular waves and ninth means responsive to said second and seventh means for generating a signal corresponding to said interval between said P- and Q-waves including a first monostable multivibrator circuit for generating a pulse output having a duration of approximately 100 msec. and triggered by the first rise pulse of the rectangular waves representative of a P-wave of a cardiac potential, a second multivibrator triggered by the pulse output from said first monostable multivibrator, a voltage generator reset by an output from said second monostable multivibrator to momentarily interrupt and then resume its operation, a third monostable multivibrator triggered by the rise part of a rectangular wave representative of the part from said Q-wave to said T-wave of a cardiac potential, and a sampling and holding circuit for sampling and holding the output of said voltage generator controlled by an output of said third monostable multivibrator.
 4. An automatic arrhythmia diagnosing system according to claim 1, comprising seventh means responsive to said first means for converting said wave portions into respective rectangular waves and tenth means responsive to said second and seventh means for generating a signal corresponding to said interval between said R-waves including a first monostable multivibrator triggered by a rectangular signal representative of an R-wave of cardiac potential producing a pair of outputs, a second Monostable multivibrator triggered by one of the outputs of said first monostable multivibrator, a voltage generator instantaneously reset by an output of said second monostable multivibrator to resume its operation, a sampling and holding circuit for sampling and holding the output of said voltage generator controlled by the other of said outputs of said first monostable multivibrator and a comparator for receiving as its two inputs the output of said sampling and holding circuit and the outputs of said voltage generator, said comparator generating a voltage when its two inputs are equal to each other.
 5. A system in accordance with claim 1, further comprising fifth means, responsive to said first means, for determining a predetermined number of cardiac cycles, having a basic rhythm, and further comprising sixth means responsive to said second means for generating signals representative of the mean values of the width of the QRS wave, the interval between the P- and Q-waves, and the interval of the R-waves.
 6. An automatic arrhythmia diagnosing system according to claim 5, comprising means for detecting said basic rhythm from cardiac cycles of said test subject including a shift register having a predetermined number of stages for receiving as an input signal a normal cardiac cycle having one P-wave and one QRS wave the width of which is equal to that of a preceding cardiac cycle in a predetermined number of cardiac cycles of said test subject, a plurality of first OR circuits each for receiving as its input signals outputs from predetermined stages of said shift register, a plurality of first counters for counting a predetermined number of output signals from each of said first OR circuits, a counter OR circuit for receiving all outputs from said first counters, a second counter for counting said predetermined number of cardiac cycles of said test subject, and a first appearing pulse discriminator for discriminating one from the other of the output signal from said second counter and the output signal from said counter OR circuit, said shift register successively generating output signals within the time interval between R-waves predetermined by the number of stages and the feed time of said shift register, each of said first OR circuits receiving a part of the input signals of the immediately preceding one of said first OR circuits.
 7. An automatic arrhythmia diagnosing system according to claim 6, wherein said first appearing pulse discriminator comprises a first AND circuit having an inhibit terminal and an input terminal, a first flip-flop circuit connected with said first AND circuit, a second AND circuit having an inhibit terminal and an input terminal, and a second flip-flop circuit connected with said second AND circuit, said first flip-flop circuit generating an output when an output from said counter OR circuit is applied to said input terminal of said first AND circuit, a part of said output from said first flip-flop circuit being derived from an output terminal thereof, the remaining part of said output from said first flip-flop circuit entering said inhibit terminal of said second AND circuit to inhibit said second AND circuit, said second flip-flop circuit generating an output when an output from said second counter is applied to said input terminal of said second AND circuit, a part of said output from said second flip-flop circuit being derived from an output terminal thereof, the remaining part of said output from said second flip-flop circuit entering said inhibit terminal of said first AND circuit to inhibit said first AND circuit.
 8. A system in accordance with claim 6, wherein said mean value signal generating means comprises an adder circuit having a pair of inputs, one of which receives signals indicative of the width of said QRS waves, a pair of sample hold circuits connected in series and being supplied the output of said adder circuit, a divider circuit connected to the output of said sEries connected sample hold circuits, a feedback circuit connected as one input of said adder circuit from the output of said series connected sample hold circuit, a controlled input for each of said sample hold circuits, one of which is connected to a control input terminal means, for supplying a control input signal to said control input terminal, and the other of which is connected to said control input terminal through an inverter circuit.
 9. A system in accordance with claim 8, further including a plurality of analog gates, respectively connected to the outputs of said mean value signal generating means and responsive to the output of said plurality of first counters for obtaining a mean value QRS duration, a mean PQ interval and a means PR interval.
 10. A system in accordance with claim 1, wherein said logically combining means comprises first logic means for generating a first plurality of code signals, including a plurality of divider circuits receiving RR integral signals, a plurality of comparator circuits corresponding in number to the number of divider circuits, and being connected in series therewith and receiving at one respective input the output of the respective divider circuit and another respective input a preselected RR interval signal, a set of logical AND gates connected to the outputs of said comparator circuits and to a control input therefor for receiving a gate energizing signal, and a plurality of logic storage circuits connected to the outputs of said AND gates for registering a first set of code signals.
 11. A system in accordance with claim 10, wherein said logically combining means further comprises second logic means for generating second code signals representative of a second set of diagnostic characteristics, said second logic circuit means comprising a pair of comparator circuits for comparing a plurality of PQ interval signals, a pair of interter circuits, receiving the outputs of said comparator circuits, a storage flip-flop being logically connected to said comparator circuits and means for logically connecting said inverter circuits to said storage flip-flop and for connecting the outputs of said comparator circuits to said storage flip-flop, comprising a set of second logic AND gates, the control inputs of which are connected to a means for supplying said control inputs with a common control signal.
 12. A system in accordance with claim 11, further comprising means for combining the outputs of said first and second logic means, comprising a first plurality of OR gates and a set of combining AND gates connected in series therewith, an output AND gate for receiving the outputs of said combining AND gates, said output AND gate further including a control input and a means for supplying a pulse to energize said control input and delayed storage input and further comprising a storage flip-flop connected to one of said combining AND gates and a delay circuit connected in series therewith for supplying said delayed storage input, and a combining output logic storage flip-flop connected to said output AND gates for delivering an output signal whereby atrio-ventricular block can be diagnosed.
 13. A system in accordance with claim 1, including coding means responsive to said first means for generating coded signals representative of coded portions of said cardiac wave signal and wherein said logically combining means comprises a plurality of shift register means, connected to said coding means to receive a plurality of signals representative of coded portions of said cardiac wave signal, a triggering multivibrator, connected in parallel to the inputs of each of said shift registers, a first plurality of shift register output gates connected to each respective shift register, and a combining output shift register AND gate connected to each of the outputs of each of said shift register output gates, and an output register flip-flop, for providing a signal indicative of the presence of bigeminy ventRicular extrasystole. 